VLX1570 Key Publications
Wang, X., D’Arcy, P., Caufield, T. R., Paulus, A., Chitta, K., Mohanty, C., Gullbo, J., Chanan-Khan, A., and Linders S. Synthesis and Evaluation of Derivatives of the Proteasome Deubiquitinase Inhibitor b-AP15 Chem Biol Drug Res (2015) (http://onlinelibrary.wiley.com/doi/10.1111/cbdd.12571/full)
Chitta, K., Paulus, A., Akhtar, S., Blake, M. K. K., Caufield, T. R., Novak, A. J., Ansell, S. M., Advandi, P., Ailawadhi, S., Sher, T., Linder, S., and Chanan-Khan, A. Targeted inhibition of the deubiquitinating enzymes, USP14 and UCHL5, induces proteotoxic stress and apoptosis in Waldenströms macroglobulinaemia tumour cells. British Journal of Haematology (2015) 169(3): 377-390 (http://onlinelibrary.wiley.com/doi/10.1111/bjh.13304/suppinfo)
Sun, C., Roboti, P., Puumalainen, M.-R., Fryknäs, M., Wang, X., D’Arcy, P., Hult, M., High, S., Linder, S., and Swanton, E. Elevation of Proteasomal Substrate Levels Sensitizes Cells to Apoptosis Induced by Inhibition of Proteasomal Deubiquitinases. PLoS One (2014) Oct 6 (http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0108839 )
Tian, Z., D’Arcy, P., Wang, X., Ray, A., Tai, Y-T., Hu, Y, Carrasco, R. D., Richardson, P., Linder, S., Chauhan, D., and Anderson, K. C. A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance. Blood (2014) 123(5): 706-716 (http://www.ncbi.nlm.nih.gov/pubmed/24319254)
Brnjic S., Mazurkiewicz, M., Fryknäs, M., Sun, C., Zhang X., Larsson, R., D’Arcy, P., and Linder, S. Induction of tumor cell apoptosis by a proteasome deubiquitinase inhibitor is associated with oxidative stress. Antioxid Redox Signaling (2014) 21(17): 2271-85 (http://www.ncbi.nlm.nih.gov/pubmed/24011031)
Paulus, A., Akhtar, S., Kuranz-Blake, M., Novak, A. J., Ansell, S., Gertz, M. A., Kyle, R. A., Martin, P., Coleman, M., Ailawadhi, S., Linder, S., Chanan-Khan, A., and Chitta, K. S. Targeted Disruption of USP14 and UCHL5 with the Novel Deubiquitinase Enzyme (DUB) Inhibitor, VLX1570, Induces Immense Proteotoxicity and Cell Death in Malignant Plasma Cells. American Society of Haematology 56th Annual meeting (2014) Poster 3116 (https://ash.confex.com/ash/2014/webprogram/Paper74834.html )
Sarhan, D., Wennerberg, E., D’Arcy, P., Gurajada, D., Linder, S., and Lundqvist, A. A novel inhibitor of proteasome deubiquitinating activity renders tumor cells sensitive to TRAIL-mediated apoptosis by natural killer cells and T cells. Cancer Immunol Immunother (2013) 62:1359-1368 (http://www.researchgate.net/publication/236923969_A_novel_inhibitor_of_proteasome_deubiquitinating_activity_renders_tumor_cells_sensitive_to_TRAIL-mediated_apoptosis_by_natural_killer_cells_and_T_cells )
D’Arcy, P., Brnjic, S., Hägg Olofsson, M., Fryknäs, M., Lindsten, K., De Cesare, M., Perego, P., Sadeghi, B., Hassan, M., Larsson, R., and Linder, S. Inhibition of proteasome deubiquitinating activity as a new cancer therapy. Nature Medicine (2011) 17: 1636-1640 (http://www.nature.com/nm/journal/v17/n12/nm.2536/metrics/citations)